Recent publications of the Cardiovascular Research Group

2024

• Defining the miRnome of saphenous vein smooth muscle cells from patients with Type 2 Diabetes Mellitus.
  Hussain A, Asare-Amankwah Y, Qureshi S, Thornton MJ, Palmer TM, O Bolanle I, Wood IC, Turner NA, Porter KE, Tedder A, Riches-Suman K.
  Diabetology 2024;5(2):178-189
• Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction.
  Kahnert K, Soattin L, Mills RW, Wilson C, Maurya S, Sorrentino A, Al-Othman S, Tikhomirov R, van de Vegte YJ, Hansen FB, Achter J, Hu W, Zi M, Smith M, van der Harst P, Olesen MS, Olsen KB, Banner J, Jensen THL, Zhang H, Boyett MR, D'Souza A, Lundby A.
  Cardiovasc Res. 2024 Apr 25:cvae054.
• Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility.
  Tikhomirov R, Oakley RH, Anderson C, Xiang Y, Al-Othman S, Smith M, Yaar S, Torre E, Li J, Wilson LR, Goulding DR, Donaldson I, Harno E, Soattin L, Shiels HA, Morris GM, Zhang H, Boyett MR, Cidlowski JA, Mesirca P, Mangoni ME, D'Souza A.
  Circ Res. 2024 May 10;134(10):1306-1326.
• Symptomatic bradyarrhythmias in the athlete-Underlying mechanisms and treatments.
  Al-Othman S, Boyett MR, Morris GM, Malhotra A, Mesirca P, Mangoni ME, D'Souza A.
  Heart Rhythm. 2024 Feb 28:S1547-5271(24)00222-4.

2023

• VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
  Mondru AK, Aljasir MA, Alrumayh A, Nithianandarajah GN, Ahmed K, Müller J, Goldring CEP, Wilm B, Cross MJ
  Cells (2023): 12(6): 967.
• Development and Optimisation of Inhalable EGCG Nano-Liposomes as a Potential Treatment for Pulmonary Arterial Hypertension by Implementation of the Design of Experiments Approach.
  Haddad F, Mohammed N, Gopalan RC, Ayoub YA, Nasim MT, Assi KH
  Pharmaceutics. 2023; 15(2):539. 
• Non-canonical role of the sympathetic nervous system in the circadian rhythm in heart rate.
  Anderson C, Forte G, Hu W, Zhang H, Boyett MR, D’Souza A Philosophical Transactions of the Royal Society B Biological Sciences 378(1879):20220179 (2023)
• Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.
  Logantha SJRJ, Yamanushi TT, Absi M, Temple IP, Kabuto H, Hirakawa E, Quigley G, Zhang X, Gurney AM, Hart G, Zhang H, Dobrzynski H, Boyett MR, Yanni J
  Philosophical Transactions of the Royal Society B Biological Sciences 378(1879):20220178.
• Atrioventricular node dysfunction in pressure overload-induced heart failure-Involvement of the immune system and transcriptomic remodelling.
  Wilson C, Zi M, Smith M, Hussain M, D'Souza A, Dobrzynski H, Boyett MR.
  Front Pharmacol. 2023 Apr 4;14:1083910.
• Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites.
  Doyle B, Madden LA, Pamme N, Jones HS.
  RSC Adv. 2023 Sep 18;13(40):27696-27704.
• Physiologically-obtainable polyphenol exposures modulate reactive oxygen and nitrogen species signaling in the C2C12 model of skeletal muscle ageing.
  Hayes N, Fogarty M, Sadofsky L, Jones HS.
  Eur J Pharmacol. 2023 Feb 15;941:175511.
• Editorial: Trends post-COVID-19 attack: the cardiocerebral system safety remains of utmost concern.
  Nader M, Haddad G, Elies J, Kentamneni S, AlBadarin F.
  Front Physiol. 2023 Jul 11;14:1224550.
• Stromal Vascular Fraction Cells from Individuals Who Have Previously Undergone Radiotherapy Retain Their Pro-Wound Healing Properties.
  Trevor LV, Riches-Suman K, Mahajan AL, Thornton MJ.
  J Clin Med. 2023 Mar 4;12(5):2052.
• Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation.
  Park KC, Crump NT, Louwman N, Krywawych S, Cheong YJ, Vendrell I, Gill EK, Gunadasa-Rohling M, Ford KL, Hauton D, Fournier M, Pires E, Watson L, Roseman G, Holder J, Koschinski A, Carnicer R, Curtis MK, Zaccolo M, Hulikova A, Fischer R, Kramer HB, McCullagh JSO, Trefely S, Milne TA, Swietach P.
  Nat Cardiovasc Res. 2023 Dec;2(12):1221-1245.
• Skeletal muscle adaptation to indirect electrical stimulation: divergence between microvascular and metabolic adaptations.
  Kissane RWP, Hauton D, Tickle PG, Egginton S.
  Exp Physiol. 2023 Jun;108(6):891-911.
• On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart.
  Kadir AA, Stubbs BJ, Chong CR, Lee H, Cole M, Carr C, Hauton D, McCullagh J, Evans RD, Clarke K.
  J Physiol. 2023 Apr;601(7):1207-1224.

2022

• Atrioventricular node dysfunction in pressure overload-induced heart failure Involvement of the immune system and transcriptomic remodelling
  Wilson, C., Zi, M., Smith, M., Hussain, M., D’Souza, A., Dobrzynski, H., Boyett, M.R.
  Frontiers in Pharmacology, 14:1083910. 2022
• Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing.
  Riches-Suman K, Hussain A.
  Biochim Biophys Acta Mol Basis Dis. 2022 Jul 1;1868(7):166403.
• Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis.
  Ross RL, Mavria G, Del Galdo F, Elies J
  Front Physiol. 2022 May 5;13:900631
• Efficacy of interval exercise training to improve vascular health in sedentary postmenopausal females.
  Lyall GK, Birk GK, Harris E, Ferguson C, Riches-Suman K, Kearney MT, Porter KE, Birch KM.
  Physiol Rep. 2022 Aug;10(16):e15441
• Impact of Pharmacist-Led Interventions to Improve Clinical Outcomes for Adults With Type 2 Diabetes at Risk of Developing Cardiovascular Disease: A Systematic Review and Meta-analysis.
  Alabkal RM, Medlinskiene K, Silcock J, Graham A.
  J Pharm Pract. 2022 May 17:8971900211064459
• Preservation of Smooth Muscle Cell Integrity and Function: A Target for Limiting Abdominal Aortic Aneurysm Expansion?
  Clark ER, Helliwell RJ, Bailey MA, Hemmings KE, Bridge KI, Griffin KJ, Scott DJA, Jennings LM, Riches-Suman K, Porter KE.
  Cells. 2022 Mar 19;11(6):1043
• Investigation of Cell Adhesion and Cell Viability of the Endothelial and Fibroblast Cells on Electrospun PCL, PLGA and Coaxial Scaffolds for Production of Tissue Engineered Blood Vessel.
  Bazgir M, Saeinasab M, Zhang W, Zhang X, Min Tsui K, Maasoumi Sarvestani A, Nawaz S, Coates P, Youseffi M, Elies J, Sefat F. J
  Funct Biomater. 2022 Dec 8;13(4):282.
• The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.
  Dearlove DJ, Soto Mota A, Hauton D, Pinnick K, Evans R, Miller J, Fischer R, Mccullagh JSO, Hodson L, Clarke K, Cox PJ.
  Physiol Rep. 2022 May;10(10):e15309.

2021

• The Functional Role of Hyperpolarization Activated Current (I f) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study.
  Bai X, Wang K, Boyett MR, Hancox JC, Zhang H.
  Front Physiol. 2021 Aug 19;12:582037.
• Diverse roles of microRNA-145 in regulating smooth muscle (dys)function in health and disease.
  Riches-Suman K.
  Biochem Soc Trans. 2021 Feb 26;49(1):353-363.
• Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering.
  Bazgir M, Zhang W, Zhang X, Elies J, Saeinasab M, Coates P, Youseffi M, Sefat F.
  Materials (Basel). 2021 Oct 22;14(21):6295.
• Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease.
  Boyett MR, Yanni J, Tellez J, Bucchi A, Mesirca P, Cai X, Logantha SJRJ, Wilson C, Anderson C, Ariyaratnam J, Stuart L, Nakao S, Abd Allah E, Jones S, Lancaster M, Stephenson R, Chandler N, Smith M, Bussey C, Monfredi O, Morris G, Billeter R, Mangoni ME, Zhang H, Hart G, D'Souza A.
  Prog Biophys Mol Biol. 2021 Nov;166:61-85.
• Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering.
  Bazgir M, Zhang W, Zhang X, Elies J, Saeinasab M, Coates P, Youseffi M, Sefat F.
  Materials (Basel). 2021 Aug 24;14(17):4773.
• Emerging roles of protein O-GlcNAcylation in cardiovascular diseases: Insights and novel therapeutic targets.
  Bolanle IO, Riches-Suman K, Williamson R, Palmer TM.
  Pharmacol Res. 2021 Mar;165:105467.
• Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit.
  Logantha SJRJ, Cai XJ, Yanni J, Jones CB, Stephenson RS, Stuart L, Quigley G, Monfredi O, Nakao S, Oh IY, Starborg T, Kitmitto A, Vohra A, Hutcheon RC, Corno AF, Jarvis JC, Dobrzynski H, Boyett MR, Hart G.
  Circ Heart Fail. 2021 Jul;14(7):e007505.
• Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation.
  Bolanle IO, Riches-Suman K, Loubani M, Williamson R, Palmer TM.
  Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1349-1356.
• Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension.
  Sharmin N, Nganwuchu CC, Nasim MT.
  Trends Pharmacol Sci. 2021 Jul;42(7):510-513.
• Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes.
  Mesirca P, Nakao S, Nissen SD, Forte G, Anderson C, Trussell T, Li J, Cox C, Zi M, Logantha S, Yaar S, Cartensen H, Bidaud I, Stuart L, Soattin L, Morris GM, da Costa Martins PA, Cartwright EJ, Oceandy D, Mangoni ME, Jespersen T, Buhl R, Dobrzynski H, Boyett MR, D'Souza A.
  Circ Res. 2021 Jun 25;129(1):e1-e20.
• Role of MicroRNA-145 in DNA Damage Signalling and Senescence in Vascular Smooth Muscle Cells of Type 2 Diabetic Patients.
  Hemmings KE, Riches-Suman K, Bailey MA, O'Regan DJ, Turner NA, Porter KE.
  Cells. 2021 Apr 16;10(4):919.
• RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart.
  Wang Y, Anderson C, Dobrzynski H, Hart G, D'Souza A, Boyett MR.
  Sci Rep. 2021 Feb 11;11(1):3565.
• Laser Capture Microdissection on Surgical Tissues to Identify Aberrant Gene Expression in Impaired Wound Healing in Type 2 Diabetes.
  Williams R, Castellano-Pelicena I, Al-Rikabi AHA, Sikkink SK, Baker R, Riches-Suman K, Thornton MJ.
  J Vis Exp. 2021 Jan 13;(167).
• Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia.
  Bidaud I, D'Souza A, Forte G, Torre E, Greuet D, Thirard S, Anderson C, Chung You Chong A, Torrente AG, Roussel J, Wickman K, Boyett MR, Mangoni ME, Mesirca P.
  Front Physiol. 2021 Jan 20;11:519382.
• Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses.
  Al-Rikabi AHA, Tobin DJ, Riches-Suman K, Thornton MJ.
  Sci Rep. 2021 Jan 14;11(1):1474.
• A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate.
  D'Souza A, Wang Y, Anderson C, Bucchi A, Baruscotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, Black N, Cox C, Wegner S, Bano-Otalora B, Petit C, Gill E, Logantha SJRJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, da Costa Martins PA, Piggins HD, DiFrancesco D, Boyett MR.
  Heart Rhythm. 2021 May;18(5):801-810.
• Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart.
  Savic D, Ball V, Holzner L, Hauton D, Timm KN, Curtis MK, Heather LC, Tyler DJ.
  NMR Biomed. 2021 Apr;34(4):e4471.
• L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI.
  Savic D, Ball V, Curtis MK, Sousa Fialho MDL, Timm KN, Hauton D, West J, Griffin J, Heather LC, Tyler DJ.
  Metabolites. 2021 Mar 23;11(3):191.