Medicinal Chemistry
The Medicinal Chemistry Team at the Institute is responsible for the design and synthesis of chemical compounds which are then evaluated for their biological activity and pharmacokinetic profile.
The team comprises a variety of expertise ranging from computer modelling to small and large scale synthesis. Our scientists use their expertise and the latest techniques to synthesise both individual as well as libraries of compounds for biological screening.
Our medicinal chemistry research is supported by post-doctoral research assistants, PhD students, MSc and MChem undergraduate project students. We annually welcome chemistry ERASMUS summer students from ESCOM and Sigma-Clermont (France) and the University of Turin (Italy), and frequently host undergraduate placements from other UK universities including York, Oxford, Leeds, and the University of Lisbon (Portugal).
Medicinal chemistry facilities
The YCR medicinal chemistry laboratories include facilities for the following:
- 20 fumehoods across two medicinal chemistry laboratories, as well as additional space comprising two preparation rooms, a walk-in cold room, a store room, write up area and offices
- Key equipment for synthetic chemistry, including dedicated LC-MS, polarimeter, UV spectrophotometer, analytical and preparative HPLC, automated peptide synthesiser
- Access to analytical instruments required for synthetic chemistry in the neighbouring Analytical Centre, including automated 400 MHz NMR for routine work and a 600 MHz NMR, facility for single crystal structure determination, mass spectrometers for low and high resolution mass determination as well as a ToF-MS, GC-MS, IR, Raman spectroscopy, etc
