Recent Publications & books
2023
Cotman, A.E., Durcik, M., Tiz, D.B., Fulghri F., Decci, D., Sterle, M., Mozina, S., Skok, Z., Zidar, N., Zega, A., Ilas, J., Masic, L.P., Tomasic, T., Hughes, D., Huseby, D., Simoff, I., Svensson, R., Korol, S., Jin Z., Vincente, F., Glinghammer, B., Lenhammar, L., Henderson S.R., Mundy, J., Maxwell, A.M., Stevenson, C.E.M., Lawson, D.M., Janssen, G., Sterk, G.J., Kikelj, D. (2023) Discovery and Hit-to-lead optimization of benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas aeruginosa. Journal of Medicinal Chemistry. , DOI: https://doi.org/10.1021/acs.jmedchem.2c01597
Takebayashi, Y.*, Henderson, S.R.*, Chirgadze, D., Warburton, P.J., Evans, B.A. (2022) OXA-66 structure and oligomerization of OXAAb enzymes. Access Microbiology. DOI: https://doi.org/10.1099/acmi.0.000412 . *Equal contribution.
Guo-Dong Chen, Iqra Fatima, Qin Xu, Elena Rozhkova, Michael Y. Fessing, Andrei N. Mardaryev, Andrei A. Sharov, Guo-Liang Xu, Vladimir A. Botchkarev. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation. Science Advances Vol 9 Number 2. https://www.science.org/doi/10.1126/sciadv.abo7605
Sterle, M., Durcik, M., Henderson, S.R., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Cahard, D., Kikelj, D., Zidar, N., Pal, C., Masic, L.P., Ilas, J., Tomasic, T., Cotman, A.E., and Zega, A. Exploring the 5-subsituted 2-aminobenzothiazole-based DNA gyrase B inhibitors active against ESKAPE pathogens. ACS Omega In Press
2022
Steel L, Ansell DM, Amaya E, Cartmell SH. Ppia and ywhaz constitute a stable pair of reference genes during electrical stimulation in mesenchymal stem cells. Appl. Sci. 2022, 12(1), 153; https://doi.org/10.3390/app12010153
Crompton RA, Williams H, Campbell L, Hui Kheng L, Saville C, Ansell DM, Reid A, Wong J, Vardy LA, Hardman MJ, Cruickshank SM. An Epidermal-Specific Role for Arginase1 during Cutaneous Wound Repair. J Invest Dermatol. 2022 Apr;142(4):1206-1216.e8. doi: 10.1016/j.jid.2021.09.009.
Fatima I, Chen G, Botchkareva NV, Sharov AA, Thornton D, Wilkinson HN, Hardman MJ, Grutzkau A, Pedro de Magalhaes J, Seluanov A, Smith ESJ, Gorbunova V, Mardaryev AN, Faulkes CG, Botchkarev VA. Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. J Invest Dermatol. 2022 Nov;142(11):2853-2863.e4. doi: 10.1016/j.jid.2022.04.028. Epub 2022 Jun 9. PMID: 35691364; PMCID: PMC9613526.
Chua KO, Norton P, Trus P, Katsikogianni M, Thornton MJ, Chan KG, Chang CY. Draft Genome Sequence of the Multiple Antibiotic Resistant Pseudomonas aeruginosa PAO1-UB Subline. Microbiol Resour Announc. 2022 Sep 15;11(9):e0064622. doi: 10.1128/mra.00646-22. Epub 2022 Aug 22. PMID: 35993720; PMCID: PMC9476901.
Chua KO, Fatima I, Lau YY, Hong KW, Yin WF, Mardaryev A, Chan KG, Chang CY. Bacterial microbiome of faecal samples of naked mole-rat collected from the toilet chamber. BMC Res Notes. 2022 Mar 18;15(1):107. doi: 10.1186/s13104-022-06000-8. PMID: 35303951; PMCID: PMC8932300.
Norton P, Chua KO, Katsikogianni M, Thornton MJ, Chan KG, Chang CY. Draft Genome Sequence of a Multiple Antibiotic Resistant Staphylococcus aureus NCTC 6571-UB Laboratory Strain. Microbiol Resour Announc. 2022 Sep 15;11(9):e0044822. doi: 10.1128/mra.00448-22. Epub 2022 Aug 23. PMID: 35997498; PMCID: PMC9476917.
Wilkinson EL, Brennan LC, Harrison OJ, Crane-Smith Z, Gautier P, Keighren MA, Budd P, Swaminathan K, Machesky LM, Allinson SL, Jackson IJ, Mort RL. Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage. Pigment Cell Melanoma Res. 2022 Nov 22. doi: 10.1111/pcmr.13076. Epub ahead of print. PMID: 36412082.
Rushton DH, Westgate GE, Van Neste DJ. Following historical "tracks" of hair follicle miniaturisation in patterned hair loss: Are elastin bodies the forgotten aetiology? Exp Dermatol. 2022 Feb;31(2):102-109. doi: 10.1111/exd.14393. Epub 2021 Jun 11. PMID: 34008225; PMCID: PMC9290669.
Clark ER, Helliwell RJ, Bailey MA, Hemmings KE, Bridge KI, Griffin KJ, Scott DJA, Jennings LM, Riches-Suman K, Porter KE. Preservation of Smooth Muscle Cell Integrity and Function: A Target for Limiting Abdominal Aortic Aneurysm Expansion? Cells. 2022 Mar 19;11(6):1043. doi: 10.3390/cells11061043. PMID: 35326494; PMCID: PMC8947535.
2021
2020
Williams R, Castellano Pellicena I, Sikkink S, Baker R, Riches-Suman K, Thornton M. Laser capture microdissection on surgical tissues to identify aberrant gene expression in impaired wound healing in Type 2 diabetes. J. Journal of Visualized Experiments (accepted 03/12/2020).
Dell’Acqua, G.; Richards, A.; Thornton, M.J. The Potential Role of Nutraceuticals as an Adjuvant in Breast Cancer Patients to Prevent Hair Loss Induced by Endocrine Therapy. Nutrients 2020, 12, 3537.
Sikkink, S.K., Mine, S., Freis, O. et al. Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp. Sci Rep 10, 18711 (2020). https://doi.org/10.1038/s41598-020-75334-9
Salgado D, Armean IM, Baudis M et al. The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research [version 1; peer review: awaiting peer review]. F1000Research 2020, 9(ELIXIR):1229 (https://doi.org/10.12688/f1000research.24887.1)
Williams, R., Pawlus, A.D. and Thornton, M.J. (2020), Getting under the skin of hair aging: the impact of the hair follicle environment. Exp Dermatol. Accepted Author Manuscript. https://doi.org/10.1111/exd.14109
Trevor, L.V.; Riches-Suman, K.; Mahajan, A.L.; Thornton, M.J. Adipose Tissue: A Source of Stem Cells with Potential for Regenerative Therapies for Wound Healing. J. Clin. Med. 2020, 9, 2161.
Katarzyna Murat, Björn Grüning, Paulina Wiktoria Poterlowicz, Gillian Westgate, Desmond J Tobin, Krzysztof Poterlowicz. Ewastools: Infinium Human Methylation BeadChip pipeline for population epigenetics integrated into Galaxy, GigaScience, Volume 9, Issue 5, May 2020, giaa049, https://doi.org/10.1093/gigascience/giaa049
Abubakar, A., Ugail, H., Smith, K.M. et al. Burns Depth Assessment Using Deep Learning Features. J. Med. Biol. Eng. 40, 923–933 (2020). https://doi.org/10.1007/s40846-020-00574-z
Baker R., Thornton M.J. (2020) Isolation of Epidermal and Hair Follicle Melanocytes. In: Botchkareva., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_3
Williams R., Thornton M.J. (2020) Isolation of Different Dermal Fibroblast Populations from the Skin and the Hair Follicle. In: Botchkareva ., Westgate G. (eds) Molecular Dermatology. Methods in Molecular Biology, vol 2154. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0648-3_2
Kang, H, Wu, W‐Y, Yu, M, Shapiro, J, McElwee, KJ. Increased expression of TLR7 and TLR9 in alopecia areata. Exp Dermatol. 2020; 29: 254–258. https://doi.org/10.1111/exd.14043
Siah, TW, Guo, H, Chu, T, et al. Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study. Exp Dermatol. 2020; 29: 334– 340. https://doi.org/10.1111/exd.14074
Zhang, X, McElwee, KJ. Allergy promotes alopecia areata in a subset of patients. Exp Dermatol. 2020; 29: 239– 242. https://doi.org/10.1111/exd.14027
2019
Mohammed I. Ahmed, Maximilian E. Pickup, Alexander G. Rimmer, Majid Alam, Andrei N. Mardaryev, Krzysztof Poterlowicz, Natalia V. Botchkareva, Vladimir A. Botchkarev. Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging, Journal of Investigative Dermatology, Volume 139, Issue 12, 2019, Pages 2538-2542.e2
2018
Nwogu N, Boyne JR, Dobson SJ, Poterlowicz K, Blair GE, Macdonald A, Mankouri J, Whitehouse A. Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness. PLoS Pathog. 2018 Sep 6;14(9):e1007276. doi: 10.1371/journal.ppat.1007276. eCollection 2018 Sep. PMID: 30188954
Joly‐Tonetti, N., Wibawa, J., Bell, M. and Tobin, D. (2018), An explanation for the mysterious distribution of melanin in human skin: a rare example of asymmetric (melanin) organelle distribution during mitosis of basal layer progenitor keratinocytes. Br J Dermatol, 179: 1115-1126. https://doi.org/10.1111/bjd.16926
Fajuyigbe, D., Lwin, S.M., Diffey, B.L., Baker, R., Tobin, D.J., Sarkany, R.P.E. and Young, A.R. (2018), Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes. The FASEB Journal, 32: 3700-3706. https://doi.org/10.1096/fj.201701472R
Akhbari P, Tobin D, Poterlowicz K, Roberts W, Boyne JR.MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis. J Invest Dermatol. 2018 May 17. pii: S0022-202X(18)31958-4. doi: 10.1016/j.jid.2018.03.1527. [Epub ahead of print]
Mignon C, Uzunbajakava NE, Castellano-Pellicena I, Botchkareva NV, Tobin DJ. Differential response of human dermal fibroblast subpopulations to visible and near-infrared light: Potential of photobiomodulation for addressing cutaneous conditions. Lasers Surg Med. 2018 Apr 17. doi: 10.1002/lsm.22823. [Epub ahead of print]
Mignon C, Tobin DJ, Zeitouny M, Uzunbajakava NE. Shedding light on the variability of optical skin properties: finding a path towards more accurate prediction of light propagation in human cutaneous compartments. Biomed Opt Express. 2018 Jan 29;9(2):852-872. doi: 10.1364/BOE.9.000852. eCollection 2018 Feb 1.
Stakaitytė G, Nwogu N, Lippiat JD, Blair GE, Poterlowicz K, Boyne JR, Macdonald A, Mankouri J, Whitehouse A. The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility. J Biol Chem. 2018 Mar 23;293(12):4582-4590. doi: 10.1074/jbc.RA117.001343. Epub 2018 Feb 8.
Fajuyigbe D, Lwin SM, Diffey BL, Baker R, Tobin DJ, Sarkany RPE, Young AR. Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes. FASEB J. 2018 Jul;32(7):3700-3706. doi: 10.1096/fj.201701472R. Epub 2018 Feb 2.
Tafazzoli A, Forstner AJ, Broadley D, Hofmann A, Redler S, Petukhova L, Giehl KA, Kruse R, Blaumeiser B, Böhm M, Bertolini M, Rossi A, Garcia Bartels N, Lutz G, Wolff H, Blume-Peytavi U, Soreq H, Christiano AM, Botchkareva NV, Nöthen MM, Betz RC. Genome-Wide MicroRNA Analysis Implicates miR-30b/d in the Etiology of Alopecia Areata. J Invest Dermatol. 2018 Mar;138(3):549-556. doi: 10.1016/j.jid.2017.09.046. Epub 2017 Dec 6.
Miranda BH, Charlesworth MR, Tobin DJ, Sharpe DT, Randall VA. Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life. FASEB J. 2018 Feb;32(2):795-806. doi: 10.1096/fj.201700260RR. Epub 2018 Jan 4.
Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR. Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1.
Botchkarev V.A., Sharov A.A., Fessing M.Y. (2018) All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration. In: Botchkarev V., Millar S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_1
Botchkareva N.V., Yi R. (2018) Orchestrated Role of microRNAs in Skin Development and Regeneration. In: Botchkarev V., Millar S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_7
Mardaryev A.N. (2018) Epigenetic Regulation of Skin Wound Healing. In: Botchkarev V., Millar S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_12
Miranda, B.H., Charlesworth, M.R., Tobin, D.J., Sharpe, D.T. and Randall, V.A. (2018), Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life. The FASEB Journal, 32: 795-806. https://doi.org/10.1096/fj.201700260RR
Bertolini M, Botchkareva N, Westgate G, et al. Bridging the "Dead Hair"-"Live Follicle" Divide in Applied Hair Research. Journal of Cosmetic Science. 2018 Sep/Oct;69(5):315-322.
Nwogu N, Boyne JR, Dobson SJ, Poterlowicz K, Blair GE, Macdonald A, et al. (2018) Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness. PLoS Pathog 14(9): e1007276. https://doi.org/10.1371/journal.ppat.1007276
2017
Buscone, S., Mardaryev, A.N., Raafs, B., Bikker, J.W., Sticht, C., Gretz, N., Farjo, N., Uzunbajakava, N.E. and Botchkareva, N.V. (2017), A new path in defining light parameters for hair growth: Discovery and modulation of photoreceptors in human hair follicle. Lasers Surg. Med., 49: 705-718. https://doi.org/10.1002/lsm.22673
Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY. 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells. PLoS Genet. 2017 Sep 1;13(9):e1006966. doi: 10.1371/journal.pgen.1006966. eCollection 2017 Sep. PubMed PMID: 28863138.
Alharbi RA, Pandha HS, Guy R. Simpson GR, Pettengell R, Poterlowicz K, Thompson A, Harrington K, El-Tanani M, Morgan R. Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells. Oncotarget. 2017; 8:89566-89579. https://doi.org/10.18632/oncotarget.20023
Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR. Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. J Invest Dermatol. 2017 Aug 31. pii: S0022-202X(17)32834-8. doi: 10.1016/j.jid.2017.08.019. [Epub ahead of print] PubMed PMID: 28867657.
Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017 Feb;26(1):37-46. doi: 10.1016/j.jtv.2016.03.002. Epub 2016 Mar 14. PubMed PMID:27020864.
Botchkarev VA. Second International Symposium-Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases. J Invest Dermatol. 2017 Aug;137(8):1604-1608. doi: 10.1016/j.jid.2017.01.037. Epub 2017 Jun 2. PubMed PMID: 28583676.
Messenger AG, Botchkareva NV. Unraveling the secret life of the hair follicle: from fungi to innovative hair loss therapies. Exp Dermatol. 2017 Jun;26(6):471. doi: 10.1111/exd.13384. PubMed PMID: 28608517.
Westgate GE, Ginger RS, Green MR. The biology and genetics of curly hair. Exp Dermatol. 2017;26:483–490. https://doi.org/10.1111/exd.13347
Singh, SK, Baker, R, Sikkink, SK, et al. E‐cadherin mediates ultraviolet radiation‐ and calcium‐induced melanin transfer in human skin cells. Exp Dermatol. 2017; 26: 1125– 1133. https://doi.org/10.1111/exd.13395
Aunin, E., Broadley, D., Ahmed, M.I. et al. Exploring a Role for Regulatory miRNAs In Wound Healing during Ageing:Involvement of miR-200c in wound repair. Sci Rep 7, 3257 (2017). https://doi.org/10.1038/s41598-017-03331-6
Mignon, C., Uzunbajakava, N.E., Raafs, B. et al. Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome. Sci Rep 7, 2797 (2017). https://doi.org/10.1038/s41598-017-02802-0